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Glossary
| SPC | Summary of Product Characteristics (UK) |
Treating dandruff and other conditions of the scalp and skin.
Dandrex Lotion is a cytostatic agent. It works by reducing skin cell growth and inhibiting growth of organisms associated with chronic flaking and itching.
Contact your doctor or health care provider right away if any of these apply to you.
Some medical conditions may interact with Dandrex Lotion. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
Some MEDICINES MAY INTERACT with Dandrex Lotion. Because little, if any, of Dandrex Lotion is absorbed into the blood, the risk of it interacting with another medicine is low.
Ask your health care provider if Dandrex Lotion may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Use Dandrex Lotion as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Dandrex Lotion.
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Hair discoloration (minimized by thorough rinsing); increase in mild hair loss or thinning; oiliness or dryness of hair and scalp.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
See also: Dandrex side effects (in more detail)
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center ( http://www.aapcc.org), or emergency room immediately. Dandrex Lotion may be harmful if swallowed.
Store Dandrex Lotion below 86 degrees F (30 degrees C) in a tightly closed container. Store away from heat and light. Keep Dandrex Lotion out of the reach of children and away from pets.
This information is a summary only. It does not contain all information about Dandrex Lotion. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
Class: Direct-acting Skeletal Muscle Relaxants
VA Class: MS200
CAS Number: 24868-20-0
Brands: Dantrium
Risk of developing potentially fatal, hepatic injury (e.g., hepatitis); should not be used for unlabeled indications.109
Females, patients >35 years of age, and those receiving other drugs (especially estrogens) concomitantly are at greatest risk.109
Risk of symptomatic hepatitis (fatal and nonfatal) may be dose dependent; incidence much higher at dosages ≥800 mg daily than at dosages ≤400 mg daily.109 Even intermittent, short courses at higher dosages associated with increased risk.109 Use lowest possible effective dose.109
Overt hepatitis most frequently observed between 3rd and 12th month of therapy.109
Frequently monitor hepatic function.109 (See Hepatic Effects under Cautions.)
If benefits are not evident within 45 days, discontinue therapy.109
Skeletal muscle relaxant.108 109
Oral management of spasticity resulting from upper motor neuron disorders (e.g., multiple sclerosis, cerebral palsy, spinal cord injury, stroke syndrome).109
Ineffective in the treatment of amyotrophic lateral sclerosis (ALS).a
Not indicated for the treatment of muscle spasms resulting from rheumatic disorders or musculoskeletal trauma.109 a
IV treatment of fulminant hypermetabolism of skeletal muscle that is characteristic of malignant hyperthermia crisis;108 should be used with and not as a substitute for supportive measures.a
Preoperative and postoperative prevention or attenuation of malignant hyperthermia in susceptible individuals; used orally or IV (when oral therapy is not practical or feasible).108 109
Has been used for the treatment of neuroleptic malignant syndrome†; fatalities reported despite therapy with the drug.108 109
Establish therapeutic goal before initiating therapy.109 Use lowest possible effective dosage.109 Discontinue drug if beneficial effects are not attained within 45 days.109 (See Boxed Warning.)
Subjective impressions of improvement may sometimes be confirmed by withdrawal of the drug for 2–4 days.109
Immediately discontinue all anesthetic agents and institute IV dantrolene as soon as malignant hyperthermia crisis is recognized.108
Monitor vital signs; employ the usual precautions associated with surgery in susceptible patients, since malignant hyperthermia may only be attenuated rather than prevented.108
Administer orally or by continuous IV infusion or rapid IV injection.108 109
Administer orally 1–4 times daily.109
To prepare oral suspension containing 25 mg of dantrolene sodium per 5 mL, empty 5 100-mg capsules in 50 mL of Syrup NF, then add a solution containing 150 mg of citric acid in 10 mL of water followed by a sufficient volume of Syrup NF to make 100 mL.c Mix thoroughly before use.c
For solution compatibility information, see Compatibility under Stability.
For IV infusion, transfer reconstituted solution from the appropriate number of vials to plastic infusion bag.109 Do not use large glass containers; precipitate formation observed with some glass containers.108
Avoid extravasation (injection has high pH).108
Add 60 mL of sterile water for injection (without bacteriostatic agent) to vial containing 20 mg of dantrolene sodium.108 Shake vial until solution is clear.108
Although reconstituted solutions are stable for 6 hours,108 infusions preferably should be prepared immediately before use.a
Preoperative prophylaxis: Infuse IV over approximately 1 hour beginning about 1.25 hours before anticipated anesthesia.108
Treatment of malignant hyperthermia syndrome: Rapid IV injection.108
Available as dantrolene sodium; dosage expressed in terms of the salt.108 109
Children ≥5 years of age: 0.5 mg/kg once daily for 7 days, followed by 0.5 mg/kg 3 times daily for 7 days, then 1 mg/kg 3 times daily for 7 days, and then 2 mg/kg 3 times daily, if necessary.109 Some patients may require doses 4 times daily.109
If no additional benefit is observed at the next higher dosage, decrease dosage to the previous (lower) dosage.109
4–8 mg/kg daily in 3 or 4 divided doses for 1–2 days prior to surgery; give the last dose approximately 3–4 hours before surgery with small amount of water.109
2.5 mg/kg infused over approximately 1 hour beginning about 1.25 hours before anticipated anesthesia; may give additional individualized doses intraoperatively, if necessary.108
Initially, 1 mg/kg or more by rapid IV injection.108 Repeat dose as necessary until physiologic and metabolic abnormalities subside or a maximum total dosage of 10 mg/kg is reached.108
Average total dosage: 2.5 mg/kg.a
Repeat regimen if physiologic and metabolic abnormalities reappear.108
4–8 mg/kg daily in 4 divided doses for up to 3 days after the crisis.109
Initially, 1 mg/kg or more as clinically indicated.108 Individualize subsequent doses.108
Initially, 25 mg once daily for 7 days, followed by 25 mg 3 times daily for 7 days, then 50 mg 3 times daily for 7 days, and then 100 mg 3 times daily, if necessary.109 Some patients may require doses 4 times daily.109
If no additional benefit is observed at the next higher dosage, decrease dosage to the previous (lower) dosage.109
4–8 mg/kg daily in 3 or 4 divided doses for 1–2 days prior to surgery; give the last dose approximately 3–4 hours before surgery with small amount of water.109
2.5 mg/kg infused over approximately 1 hour beginning about 1.25 hours before anticipated anesthesia; may give additional individualized doses intraoperatively, if necessary.108
Initially, 1 mg/kg or more by rapid IV injection.108 Repeat dose as necessary until physiologic and metabolic abnormalities subside or a maximum total dosage of 10 mg/kg is reached.108
Average total dosage: 2.5 mg/kg.a
Repeat regimen if physiologic and metabolic abnormalities reappear.108
4–8 mg/kg daily in 4 divided doses for up to 3 days after the crisis.109
Initially, 1 mg/kg or more as clinically indicated.108 Individualize subsequent doses.108
Maximum 100 mg 4 times daily.109
Maximum 10 mg/kg.108
Maximum 100 mg 4 times daily.109
Maximum 10 mg/kg.108
Oral dantrolene contraindicated in patients with active hepatic disease (e.g., hepatitis, cirrhosis).109
Also contraindicated in patients who must utilize spasticity to maintain upright posture and balance in moving or to obtain or maintain increased body function.109
No contraindications to IV dantrolene for prophylaxis or management of malignant hyperthermia crisis.108
Fatal and nonfatal hepatic disorders of idiosyncratic or hypersensitivity type possible with oral dantrolene.108 109 (See Boxed Warning.)
Obtain serum AST, ALT, alkaline phosphatase, and total bilirubin concentrations prior to and periodically during therapy or whenever symptoms of hepatitis occur.109
If liver function test abnormalities occur alone, consider discontinuing therapy; continue or reinstitute the drug only if major benefits occurred during dantrolene therapy.109
If symptoms of hepatitis are accompanied by liver function test abnormalities or jaundice, discontinue dantrolene.109
Following discontinuance for clinical and/or laboratory evidence of hepatotoxicity, reinstitute dantrolene only in patients who clearly need the drug and only after symptoms and laboratory abnormalities of hepatotoxicity have resolved.109 Hospitalize patient to reinitiate therapy with very small doses; gradually increase dosage with frequent monitoring of liver function; discontinue drug immediately if signs of liver abnormality recur.109
Long-term safety in humans yet to be established.109
Nephropathy, benign and malignant mammary and testicular tumors, hepatic lymphangiomas, and hepatic angiosarcomas reported following long-term use in animals; assess risk/benefits of chronic administration.109
Possible photosensitivity reactions; limit exposure to sunlight.109
Performance of activities requiring mental alertness may be impaired.108 109
Concurrent use of other CNS depressants may potentiate CNS depression.108 109 (See Specific Drugs under Interactions.)
If mannitol is used for the prevention or treatment of late renal complications of malignant hyperthermia, consider mannitol in the IV dantrolene formulation (3 g of mannitol per 20-mg vial) as part of the total amount administered.108
Use with caution in patients with severe cardiac impairment secondary to myocardial disease or with impaired pulmonary function (particularly obstructive pulmonary disease).109
Category C.108 109
Readily crosses the placenta.108 (See Distribution under Pharmacokinetics.)
Distributed into milk;b use of oral dantrolene not recommended.109
Long-term safety of oral dantrolene not established in children <5 years of age.109
Weigh possible risks against potential benefits before initiating long-term oral therapy; adverse effects may become evident only after many years.109
Insufficient experience in patients ≥65 years of age to determine whether geriatric patients respond differently than younger adults.108
Titrate dosage carefully.108
Use with caution in patients with a history of hepatic impairment.109
Muscle weakness, drowsiness, dizziness, lightheadedness, diarrhea, nausea, malaise, fatigue.a 109
Metabolized in the liver, but the precise enzymes responsible are unknown.108
Pharmacokinetic interaction with CYP enzyme inducers theoretically possible.108
Drug | Interaction | Comment |
|---|---|---|
Calcium-channel blockers (e.g., verapamil) | Cardiovascular collapse reported rarely108 | Concomitant use during malignant hyperthermia crisis not recommended108 |
Clofibrate | Decreased binding of dantrolene to plasma proteins108 | |
CNS depressants | Possible additive CNS effects (e.g., dizziness)108 109 | Use with caution108 109 |
Diazepam | Additive sedative effect; dantrolene metabolism and protein binding unaffacted108 | Use with cautiona |
Estrogens | Possible increased frequency of hepatotoxicity in women >35 years of age109 | Potential for interaction not clearly established; use with caution109 |
Phenobarbital | Pharmacokinetic interaction unlikely; dantrolene metabolism unaffected108 | |
Phenytoin | No change in binding of dantrolene to plasma proteins108 | |
Tolbutamide | Increased binding of dantrolene to plasma proteins108 | |
Vecuronium | Potentiation of vecuronium-induced neuromuscular blockade108 | |
Warfarin | Decreased binding of dantrolene to plasma proteins108 |
Absorption following oral administration is incomplete and slow but consistent.109
Readily crosses the placenta, with maternal and fetal whole blood concentrations approximately equal at delivery; neonatal concentrations then fall approximately 50% per day for 2 days before declining sharply.108
Substantially bound to plasma proteins (mostly albumin); binding is readily reversible.108
Specific metabolic pathways not established.108 May undergo hydrolysis and subsequent oxidation forming nitrophenylfuroic acid.108
Specific pathways not established.108
Approximately 4–8 hours following IV administration.108
Approximately 9 hours following oral administration in adults.109
<40°C.109
15–30°C.108 Avoid prolonged exposure to light.108
Store reconstituted solutions at 15–30°C for up to 6 hours.108 Protect from light.108
For information on systemic interactions resulting from concomitant use, see Interactions.
Incompatible |
|---|
Dextrose 5% in water |
Sodium chloride 0.9% |
Causes skeletal muscle relaxation through a direct effect on skeletal muscle, probably by interfering with release of calcium from the sarcoplasmic reticulum.108 109
Interference with calcium release from the sarcoplasmic reticulum may prevent the increase in myoplasmic calcium that activates acute catabolism of skeletal muscle cells in patients with anesthesia-induced malignant hyperthermia.108
Has little or no effect on the contraction of cardiac or intestinal smooth muscle, except possibly at concentrations higher than those required for effects on skeletal muscle contraction.a
Risk of hepatoxicity with oral dantrolene.108 109
Risk of dizziness and muscle weakness; use caution when driving or operating machinery.108 109 Do not drive or operate machinery within 48 hours of receiving IV dantrolene.109
Risk of choking and difficulty swallowing; exercise caution during meals.108
Risk of photosensitivity reactions; limit exposure to sunlight.109
Importance of women informing their clinician if they are or plan to become pregnant or plan to breast-feed.108 109
Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs, alcohol consumption, and any concomitant illnesses.108 109
Importance of informing patients of other important precautionary information.108 109 (See Cautions.)
Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.
* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name
Routes | Dosage Forms | Strengths | Brand Names | Manufacturer |
|---|---|---|---|---|
Oral | Capsules | 25 mg* | Dantrium | Procter & Gamble |
Dantrolene Sodium Capsules | Amide, Global | |||
50 mg* | Dantrium | Procter & Gamble | ||
Dantrolene Sodium Capsules | Amide, Global | |||
100 mg* | Dantrium | Procter & Gamble | ||
Dantrolene Sodium Capsules | Amide, Global | |||
Parenteral | For injection | 20 mg | Dantrium Intravenous (with mannitol 3 g) | Procter & Gamble |
This pricing information is subject to change at the sole discretion of DS Pharmacy. This pricing information was updated 03/2011. Actual costs to patients will vary depending on the use of specific retail or mail-order locations and health insurance copays.
Dantrium 100MG Capsules (JHP PHARMACEUTICALS): 45/$99.99 or 135/$291.99
Dantrium 25MG Capsules (JHP PHARMACEUTICALS): 45/$58.98 or 135/$164.96
Dantrium 50MG Capsules (JHP PHARMACEUTICALS): 45/$81.99 or 135/$234.97
Dantrolene Sodium 100MG Capsules (GLOBAL PHARMACEUTICAL CORP): 45/$76.99 or 135/$219.97
Dantrolene Sodium 25MG Capsules (GLOBAL PHARMACEUTICAL CORP): 30/$34.99 or 90/$81.97
Dantrolene Sodium 50MG Capsules (GLOBAL PHARMACEUTICAL CORP): 45/$63.99 or 135/$175.97
This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.
The American Society of Health-System Pharmacists, Inc. and Drugs.com represent that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. and Drugs.com make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. and Drugs.com do not endorse or recommend the use of any drug. The information is not a substitute for medical care.
AHFS Drug Information. © Copyright, 1959-2011, Selected Revisions July 2007. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.
† Use is not currently included in the labeling approved by the US Food and Drug Administration.
Only references cited for selected revisions after 1984 are available electronically.
100. Coons DJ, Hillman FJ, Marshall RW. Treatment of neuroleptic malignant syndrome with dantrolene sodium: a case report. Am J Psychiatry. 1982; 139:944-5. [IDIS 154797] [PubMed 6124135]
101. Goekoop JG, Carbaat PAT. Treatment of neuroleptic malignant syndrome with dantrolene. Lancet. 1982; 2:49-50.
102. May DC, Morris SW, Stewart RM et al. Neuroleptic malignant syndrome: response to dantrolene sodium. Ann Intern Med. 1983; 98:183-4. [IDIS 164929] [PubMed 6824251]
103. Daoudal P, Delacour JL. Treatment of neuroleptic malignant syndrome with dantrolene. Lancet. 1982; 2:217. [PubMed 6123917]
104. Granato JE, Stern BJ, Ringel A et al. Neuroleptic malignant syndrome: successful treatment with dantrolene and bromocriptine. Ann Neurol. 1983; 14:89-90. [IDIS 173103] [PubMed 6614876]
105. Goulon M, de Rohan-Chabot P, Elkharrat D et al. Beneficial effects of dantrolene in the treatment of neuroleptic malignant syndrome: a report of the two cases. Neurology. 1983; 33:516-8. [IDIS 169146] [PubMed 6682201]
106. Rappaport PL. Extemporaneous dosage preparations for pediatrics. Can J Hosp Pharm. 1983; 36:66-70,74. [PubMed 10262678]
107. Kaplan RF, Feinglass NG, Webster W et al. Phenelzine overdose treated with dantrolene sodium. JAMA. 1986; 255:642-4. [IDIS 210184] [PubMed 3944965]
108. Procter & Gamble Pharmaceuticals. Dantrium IV (dantrolene sodium) for injection prescribing information. Cincinnati, OH; 2001 May.
109. Procter & Gamble Pharmaceuticals. Dantrium (dantrolene sodium) capsules prescribing information. Cincinnati, OH; 1997 Feb.
110. Rubin AS, Zablocki AD. Hyperkalemia, verapamil, and dantrolene. Anesthesiology. 1987; 66:246-9. [IDIS 227329] [PubMed 3813090]
111. Dantrolene (Dantrium) interactions: verapamil (e.g., Calan). In: Hansten PD, Horn JR. Hansten and Horn’s drug interactions, analysis and managements. St. Louis, MO. Facts and Comparisons; 2002:450a.
a. AHFS drug information 2003. McEvoy GK, ed. Dantrolene. Bethesda, MD: American Society of Health-System Pharmacists; 2003:1321-5.
b. Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and lactation. 6th ed. Baltimore, MD: Williams & Wilkins; 2002:364-6.
c. Nahata MC, Hipple TF. Pediatric drug formulations. 4th ed. Cincinnati, Ohio: Harvey Whitney Books Company; 2000: 35.
Generic Name: darunavir (da ROON a veer)
Brand Names: Prezista
Darunavir is an antiviral medication in a group of HIV medicines called protease (PRO-tee-ayz) inhibitors. Darunavir prevents human immunodeficiency virus (HIV) cells from multiplying in your body.
Darunavir is used to treat HIV, which causes acquired immunodeficiency syndrome (AIDS). Darunavir is not a cure for HIV or AIDS.
Darunavir may also be used for purposes not listed in this medication guide.
HIV/AIDS is usually treated with a combination of drugs. Use all medications as directed by your doctor. Do not change your doses or medication schedule without your doctor's advice. Every person with HIV or AIDS should remain under the care of a doctor.
alfuzosin (Uroxatral);
cisapride (Propulsid);
pimozide (Orap);
lovastatin (Mevacor, Altoprev, Advicor) or simvastatin (Zocor, Simcor, Vytorin);
rifampin (Rifadin, Rimactane, Rifater);
sildenafil (Revatio);
St. John's wort;
triazolam (Halcion) or oral midazolam (Versed); or
ergot medicines such as ergotamine (Ergomar, Cafergot), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), or methylergonovine (Methergine).
To make sure you can safely take darunavir, tell your doctor if you have any of these other conditions:
diabetes;
a bleeding disorder such as hemophilia;
high cholesterol or triglycerides; or
if you are allergic to sulfa drugs.
Your name may need to be listed on an antiviral pregnancy registry when you start using this medication.
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Darunavir must be taken together with another medication called ritonavir (Norvir). Take the medicines together at the same time every day.
Swallow the darunavir tablet whole. Do not break or chew.
Use darunavir regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
To be sure this medication is helping your condition, your blood may need to be tested often. Your liver function may also need to be tested. Visit your doctor regularly.
HIV/AIDS is usually treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice. Every person with HIV or AIDS should remain under the care of a doctor.
See also: Darunavir dosage (in more detail)
Take the missed dose of darunavir and ritonavir as soon as you remember and take your next dose at the regularly scheduled time.
If you take darunavir 800 milligrams once daily and you are more than 12 hours late in taking your medications, skip the missed dose and take the next regularly scheduled dose. Do not take extra medicine to make up the missed dose.
If you take darunavir 600 milligrams twice daily and you are more than 6 hours late in taking your medications, skip the missed dose and take the next regularly scheduled dose.
Always take darunavir and ritonavir together. Do not take extra medicine to make up the missed dose.
If you also take didanosine (Videx), take it 1 hour before or 2 hours after you take darunavir.
fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
the first sign of any skin rash, no matter how mild;
signs of a new infection, such as fever or chills, cough, flu symptoms, easy bruising or bleeding;
severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;
nausea, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
high blood sugar (increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss);
Less serious side effects may include:
diarrhea, mild nausea, vomiting, stomach pain;
headache;
mild skin rash; or
changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for HIV Infection:
Therapy-naive patients and therapy-experienced patients with no darunavir resistance associated substitutions: Darunavir 800 mg plus ritonavir 100 mg orally once a day with food
Therapy-experienced patients with at least 1 darunavir resistance associated substitution (including V11I, V32I, L33F, I47V, I50V, I54L, I54M, T74P, L76V, I84V, and L89V): Darunavir 600 mg plus ritonavir 100 mg orally twice a day with food
Genotypic testing is recommended for therapy-experienced patients. However, when genotypic testing is not possible, darunavir 600 mg plus ritonavir 100 mg orally twice a day with food is recommended.
Usual Pediatric Dose for HIV Infection:
6 to less than 18 years:
20 to less than 30 kg: Darunavir 375 mg plus ritonavir 50 mg orally twice a day with food
30 to less than 40 kg: Darunavir 450 mg plus ritonavir 60 mg orally twice a day with food
40 kg or more: Darunavir 600 mg plus ritonavir 100 mg orally twice a day with food
Once-daily dosing is not recommended for pediatric patients.
bosentan (Tracleer);
buprenorphine and naloxone (Suboxone);
colchicine (Colcrys);
methadone (Methadose, Dolophine, Diskets);
risperidone (Risperdal) or thioridazine (Mellaril);
salmeterol (Serevent);
an antibiotic such as clarithromycin (Biaxin), rifabutin (Mycobutin);
an antidepressant such as desipramine (Norpramin), trazodone (Desyrel), and others;
an antifungal medication such as itraconazole (Sporanox), ketoconazole (Nizoral), or voriconazole (Vfend);
beta-blockers such as metoprolol (Lopressor, Toprol) or timolol (Blocadren, Betimol, Cosopt, Timoptic);
a blood thinner such as warfarin (Coumadin, Jantoven);
cholesterol-lowering medicine such as atorvastatin (Lipitor, Caduet), pravastatin (Pravachol), rosuvastatin (Crestor);
heart or blood pressure medicine such as felodipine (Plendil), nicardipine (Cardene), nifedipine (Nifedical, Procardia), and others;
medicines used to prevent organ transplant rejection, such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), or tacrolimus (Prograf);
a heart rhythm medication such as amiodarone (Cordarone), digoxin (digitalis, Lanoxin), flecainide (Tambocor), lidocaine, propafenone (Rythmol), or quinidine (Quin-G);
insulin or diabetes medication you take by mouth;
medicines to treat erectile dysfunction, such as sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra);
other HIV/AIDS medicine such as efavirenz (Sustiva, Atripla), raltegravir (Isentress), ritonavir (Norvir, Kaletra), or saquinavir (Invirase, Fortovase);
seizure medications such as carbamazepine (Carbatrol, Equetro, Tegretol), phenobarbital (Luminal, Solfoton), or phenytoin (Dilantin); or
a steroid medication such as dexamethasone (Decadron, Hexadrol) or fluticasone (Advair, Flonase, Flovent).
This list is not complete and other drugs may interact with darunavir. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
See also: darunavir side effects (in more detail)
